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PACE® Science PACE Biology Clinical Studies Scientific Literature Products Experimental Review of the Mechanisms of Action for Pulsed Acoustic Cellular Expression (PACE) Technology European Experience with Pulsed Acoustic Cellular Expression (PACE) Technology in the Treatment of Diabetic Foot Ulcers

Scientific Literature Scientific literature is being provided for educational purposes only. Not all indications are FDA approved. SANUWAVE does not claim safety or efficacy for unapproved products and treatment indications. Wound Healing Prospective Randomized Phase II Trial of Accelerated Reepithelialization of Superficial Second-Degree Burn Wounds Using Extracorporeal Shock Wave Therapy Shock Wave Therapy in Wound Healing The Influence of Comorbidities and Etiologies on the Success of Extracorporeal Shock Wave Therapy for Chronic Soft Tissue Wounds: Midterm Results Molecular Changes in Diabetic Foot Ulcers Treatment of Diabetic Foot Ulcers: A Comparative Study of Extracorporeal Shockwave Therapy and Hyperbaric Oxygen Therapy Prospective Randomized Trial of Accelerated Re-epithelization of Skin Graft Donor Sites Using Extracorporeal Shock Wave Therapy Effects of Extracorporeal Shock Wave Therapy on Wounds of the Distal Portion of the Limbs in Horses Extracorporeal Shock Waves, a New Non-surgical Method to Treat Severe Burns Extracorporeal Shock Wave Therapy Suppresses the Early Proinflammatory Immune Response to a Severe Cutaneous Burn Injury The Management of Neuropathic Ulcers of the Foot in Diabetes by Shock Wave Therapy Extracorporeal Shock Wave Therapy for Management of Chronic Ulcers in the Lower Extremities A Pilot Study of Pulsed Acoustic Wave Therapy (dermaPACETM) in the Treatment of Mid-Deep Dermal Burns PACE (Pulsed Acoustic Cellular Expression) - Technology: A New Approach to Treating Ulcers in Diabetic Patients Extracorporeal Shock-wave Therapy Enhanced Wound Healing Via Increasing Topical Blood Perfusion and Tissue Regeneration in a Rat Model of STZ-induced Diabetes Extracorporeal Shockwave Treatment for Chronic Diabetic Foot Ulcers Extracorporal Shock Wave Technology - New Approach to Treating Diabetic Ulcers: 18 - Month Follow Up Shock Wave Therapy for Acute and Chronic Soft Tissue Wounds: A Feasibility Study Extracorporeal Shockwave Therapy for Chronic Skin Lesions: Cases Reports Deep Partial Thickness Burn Injury and the Effect of ESWT: an Experimental Investigation in Rats Shock Wave Therapy: An Innovative Treatment Method for Partial Thickness Burns Effect of Shock Waves on the Healing of Partial-Thickness Wounds in Piglets Can PACE Restart Healing in Chronic Persistent Diabetic Ulcers Extracorporeal Shockwave Treatment for Chronic Diabetic Foot Ulcers The Effect of ESWT on Chronic Leg Ulcers in Diabetic Patients: A Clinical Trial Ischemia Shock Wave Treatment in Composite Tissue Allotransplantation Extracorporeal Shock Wave Therapy (ESWT) Minimizes Ischemic Tissue Necrosis Irrespective of Application Time and Promotes Tissue Revascularization by Stimulating Angiogenesis Optimal Timing of Extracorporeal Shock Wave Treatment to Protect Ischemic Tissue Comparison of Extracorporal Shock Wave Pretreatment to Classic Surgical Delay in a Random Pattern Skin Flap Model Pulsed Acoustic Cellular Treatment Induces Expression of Proangiogenic Factors and Chemokines in Muscle Flaps Extracorporeal Shock-wave Therapy Enhanced Wound Healing via Increasing Topical Blood Perfusion and Tissue Regeneration in a Rat Model of STZ-induced Diabetes Extracorporeal Shock Wave Treatment in Ischemic Tissues: What is the Appropriate Number of Shock Wave Impulses? Preoperative Shock Wave Therapy Reduces Ischemic Necrosis in an Epigastric Skin Flap Model Extracorporeal Shock Wave Therapy Ameliorates Hindlimb Ischemia in Rabbits Effects of Repeated Extracorporeal Shock Wave on Kidney Apoptosis of Normal and Diabetic Rat Extracorporeal Shock Wave Treatment Modulates Skin Fibroblast Recruitment and Leukocyte Infiltration for Enhancing Extended Skin-flap Survival Angiogenic Response to Extracorporeal Shock Wave Treatment in Murine Skin Isografts Improvement of Blood Flow, Expression of Nitric Oxide, and Vascular Endothelial Growth Factor by Low-Energy Shockwave Therapy in Random-Pattern Skin Flap Model Extracorporeal Shock Wave Enhanced Extended Skin Flap Tissue Survival via Increase of Topical Blood Perfusion and Associated with Suppression of Tissue Pro-inflammation Low-Energy Shock Wave for Enhancing Recruitment of Endothelial Progenitor Cells: A New Modality to Increase Efficacy of Cell Therapy in Chronic Hind Limb Ischemia Comparison of the Effectiveness of Gene Therapy with Vascular Endothelial Growth Factor or Shock Wave Therapy to Reduce Ischaemic Necrosis in an Epigastric Skin Flap Model in Rats Extracorporal Shock Wave May Enhance Skin Flap Survival in an Animal Model Extracorporeal Cardiac Shock Wave Therapy Markedly Ameliorates Ischemia-Induced Myocardial Dysfunction in Pigs in Vivo Effects of Shock Waves on the Microcirculation in Critical Limb Ischemia (CLI) (8 Week Study) Antibacterial Effects + Biofilm Low-energy Shock Waves Enhance the Susceptibility of Staphylococcal Biofilms to Antimicrobial Agents in Vitro Effects of Low-energy Shock Waves on Oral Bacteria Effective Prevention of Microbial Biofilm Formation on Medical Devices by Low-Energy Surface Acoustic Waves Antibacterial Effects of Extracorporeal Shock Waves Bone Treatments and Non-Unions Development of a Prognostic Naïve Bayesian Classifier for Successful Treatment of Nonunions Effects of Extracorporeal Shock Wave Therapy and Polysulfated Glycosaminoglycan Treatment on Subchondral Bone, Serum Biomarkers, and Synovial Fluid Biomarkers in Horses with Induced Osteoarthritis Shockwaves Enhance the Osteogenetic Gene Expression in Marrow Stromal Cells from Hips with Osteonecrosis Extracorporeal Shockwave Therapy Shows Chondroprotective Effects in Osteoarthritic Rat Knee Extracorporeal Shock Wave Treatment of Non- or Delayed Union of Proximal Metatarsal Fractures Extracorporeal Shock Wave Therapy for Nonunion of the Tibia Extracorporeal Shockwave Therapy Shows Regeneration in Hip Necrosis Biomechanical Testing of Spinal Fusion Segments Enhanced by Extracorporeal Shock Wave Treatment in Rabbits Extracorporeal Shock Wave Therapy for Resistant Stress Fracture in Athletes Application of Extracorporeal Shock Wave Treatment to Enhance Spinal Fusion: A Rabbit Experiment The Effects of Extracorporeal Shockwave on Acute High-energy Long Bone Fractures of the Lower Extremity Treatment for Osteonecrosis of the Femoral Head: Comparison of Extracorporeal Shock Waves with Core Decompression and Bone-Grafting Treatment of Nonunions of Long Bone Fractures with Shock Waves Effect of Shock Wave Therapy on Acute Fractures of the Tibia Long-term Follow-up of Shockwave Treatment on Heterotopic Ossifications and New Radiologic Methodologies for Evaluation Extracorporeal Shock Wave Therapy of Nonunion or Delayed Osseous Union High-Energy Shock Wave Treatment of Femoral Head Necrosis in Adults Treatment of Nonunions of Long Bone Fractures with Shock Waves Cardiovascular Extracorporeal Shock Wave Therapy Reverses Ischemia-Related Left Ventricular Dysfunction and Remodeling: Molecular-Cellular and Functional Assessment Direct Epicardial Shock Wave Therapy Improves Ventricular Function and Induces Angiogenesis in Ischemic Heart Failure Extracorporeal Cardiac Shock Wave Therapy: First Experience in the Everyday Practice for Treatment of Chronic Refractory Angina Pectoris Stem Cells Effect of Shock Wave Treatment on Platelet-Rich Plasma Added to Osteoblast Cultures Shockwaves Enhance the Osteogenetic Gene Expression in Marrow Stromal Cells from Hips with Osteonecrosis Shock Wave Therapy Applied to Rat Bone Marrow-Derived Mononuclear Cells Enhances Formation of Cells Stained Positive for CD31 and Vascular Endothelial Growth Factor Effects of Shock Waves on Tenocyte Proliferation and Extracellular Matrix Metabolism Effect of Shock Wave on the Catalytic Activity of Endothelial Nitric Oxide Synthase in Human Umbilical Vein Endothelial Cells Early Effects of Extracorporeal Shock Wave Treatment on Osteoblast-like Cells: A Comparative Study Between Electromagnetic and Electrohydraulic Devices Low-Energy Shock Wave for Enhancing Recruitment of Endothelial Progenitor Cells: A New Modality to Increase Efficacy of Cell Therapy in Chronic Hind Limb Ischemia Shockwave Stimulates Oxygen Radical-Mediated Osteogenesis of the Mesenchymal Cells From Human Umbilical Cord Blood Recruitment of Mesenchymal Stem Cells and Expression of TGF-ß1 and VEGF in the Early Stage of Shock Wave-promoted Bone Regeneration of Segmental Defect in Rats Superoxide Mediates Shock Wave Induction of ERK-dependent Osteogenic Transcription Factor (CBFA1) and Mesenchymal Cell Differentiation Toward Osteoprogenitors Extracorporeal Shock Wave Promotes Growth and Differentiation of Bone-marrow Stromal Cells Towards Osteoprogenitors Associated with Induction of TGF-ß1 Physical Shock Wave Mediates Membrane Hyperpolarization and Ras Activation for Osteogenesis in Human Bone Marrow Stromal Cells Noninvasive Shockwave-Induced Thickening of the Periosteum Tendinopathies Extracorporeal Shock Wave Therapy Enhances Early Tendon-Bone Healing and Reduces Bone Tunnel Enlargement in Hamstring Autograft Anterior Cruciate Ligament Reconstruction Extracorporeal Shockwave-Induced Expression of Lubricin in Tendons and Septa Biological Mechanism of Musculoskeletal Shockwaves Extracorporeal Shockwave for Chronic Patellar Tendinopathy Effects of Shock Waves on Tenocyte Proliferation and Extracellular Matrix Metabolism High-Energy Extracorporeal Shock Wave Therapy as a Treatment for Insertional Achilles Tendinopathy Electrohydraulic High-Energy Shock-Wave Treatment for Chronic Plantar Fasciitis Long-term Results of Extracorporeal Shockwave Treatment for Plantar Fasciitis Humeral Head Osteonecrosis After Extracorporeal Shock-Wave Treatment for Rotator Cuff Tendinopathy Extracorporeal Shock Wave Therapy for the Treatment of Chronic Calcifying Tendonitis of the Rotator Cuff Shockwave Therapy for Patients with Plantar Fasciitis: A One-Year Follow-up Study Shock Wave Therapy for Patients with Lateral Epicondylitis of the Elbow Preliminary Results on the Safety and Efficacy of the OssaTron® for Treatment of Plantar Fasciitis Shock Wave Therapy for Chronic Proximal Plantar Fasciitis Scientific literature is being provided for educational purposes only. Not all indications are FDA approved. SANUWAVE does not claim safety or efficacy for unapproved products and treatment indications.